Cerebral Amyloid Angiopathy: An Update
Cerebral amyloid angiopathy (CAA), defined as cerebrovascular deposition of the ß-amyloid peptide, is a major cause of intracerebral hemorrhage and an important contributor to vascular cognitive impairment and dementia. Although originally defined pathologically, CAA can be diagnosed during life and its course at least partially predicted by the Boston Criteria and other validated neuroimaging biomarkers. Important recent advances in CAA include recognition of its effects on cerebrovascular reactivity, its role in triggering CAA-related inflammation, and its noninvasive detection by amyloid-PET imaging. Though CAA has no disease-modifying treatment, its detection has substantial treatment implications for clinical decisions such as antithrombotic use
Prof. Steven Greenberg - Bio
Dr. Greenberg is Professor of Neurology at Harvard Medical School, Vice Chair of Neurology for Faculty Development and Promotions, and holds the John J Conway Endowed Chair in Neurology at Massachusetts General Hospital. He is recipient of the 2017 American Heart Association William M. Feinberg Award for excellence in clinical stroke and has served in many national and international leadership roles in the fields of stroke and neurology including principle investigator for the NINDS VCID biomarkers consortium coordinating center, president of the International CAA Association, chair of the NIH Acute Neurologic Injury and Epilepsy study section, co-chair of the NINDS Alzheimer’s Disease-Related Dementias Summit subcommittee on vascular cognitive impairment, and chair of the American Heart Association International Stroke Conference. Dr. Greenberg has authored over 200 peer-reviewed research articles and over 70 chapters, reviews, and editorials in the areas of hemorrhagic stroke and small vessel brain disease. He received his undergraduate degree in Biochemistry from Harvard University and MD and PhD degrees from Columbia University under the graduate research training of Dr. James Schwartz. He performed internship at Pennsylvania Hospital, neurology residency at MGH, and post-doctoral fellowship at Brigham and Women’s Hospital under the training of Dr. Kenneth Kosik.